Consistent stress, worry, indecisiveness, heartbreak, and more all lead to isolation from fear and a lack of positivity. You may wonder why you cannot seem to “snap out of it”. You may find it annoying that things seem good for a while only to have your anxiety and depression to reemerge at random times; a commercial on television, a couple holding hands, a song on the radio. You can be faced with a decision that needs to be made and you can choose and feel accomplished and other times you feel like that decision is ” life or death” and you cannot decide which way to go. Your anxiety hurts your stomach, you have heart palpitations, you cannot breathe. Anxiety and depression are prevalent with financial woes, emotional insecurities, conflicting data from persons and social media, family and academic pressures, with significant negative impact. Many patients prefer herbs for symptom relief to conventional medications which have limited efficacy/side effects. We identified single-herb medicines that may warrant further study. Our search included PubMed, Allied and Complementary Medicine, Embase, and Cochrane databases, selecting only single-herb randomized controlled trials between 1996 and 2023 in any population for data extraction, excluding herbs with known potential for interactions. One hundred articles involving 38 botanicals met our criteria. Among herbs most studied (≥6 randomized controlled trials each), lavender, passionflower, and skullcap produced benefits comparable to standard anxiolytics and antidepressants. Black cohosh, chamomile, and chasteberry are also promising. Anxiety or depressive symptoms were measured in all studies, but not always as primary endpoints. Overall, 45% of studies reported positive findings with fewer adverse effects compared with conventional medications. Based on available data, black cohosh, chamomile, chasteberry, lavender, passionflower, and skullcap are useful in mitigating anxiety or depression with favorable risk-benefit profiles compared to standard treatments. Years of formulating has brought combinations of ingredients that heal nerve endings, calm the mind and support calm and thoughfulness.